| Player | Opponent | Min | Referee | Competition | Date |
|---|---|---|---|---|---|
| Maxi Pereira | vs Costa Rica | 90' | Felix Brych | 2014 FIFA World Cup | 14 Jun 2014 |
| Luis Suárez | vs Ghana | 120' | Olegário Benquerença | 2010 FIFA World Cup | 2 Jul 2010 |
| Nicolás Lodeiro | vs France | 81' | Yuichi Nishimura | 2010 FIFA World Cup | 11 Jun 2010 |