| Player | Opponent | Min | Referee | Competition | Date |
|---|---|---|---|---|---|
| Jack Stephens | vs Chelsea | 39' | Tony Harrington | Premier League | 4 Dec 2024 |
| Ryan Fraser | vs Leicester City | 73' | Anthony Taylor | Premier League | 19 Oct 2024 |
| Jack Stephens | vs Manchester United | 79' | Stuart Attwell | Premier League | 14 Sept 2024 |
| Mohammed Salisu | vs Tottenham Hotspur | 39' | Anthony Taylor | Premier League | 28 Dec 2021 |
| James Ward-Prowse | vs Chelsea | 77' | – | Premier League | 2 Oct 2021 |
| Jannik Vestergaard | vs Leicester City | 10' | – | Premier League | 30 Apr 2021 |
| Alexandre Jankewitz | vs Manchester United | 2' | – | Premier League | 2 Feb 2021 |
| Jan Bednarek | vs Manchester United | 86' | – | Premier League | 2 Feb 2021 |
| Moussa Djenepo | vs Newcastle United | 28' | – | Premier League | 7 Mar 2020 |
| Ryan Bertrand | vs Leicester City | 12' | – | Premier League | 25 Oct 2019 |
| Kevin Danso | vs Manchester United | 73' | – | Premier League | 31 Aug 2019 |
| Yan Valery | vs Leicester City | 45' | – | Premier League | 12 Jan 2019 |
| Pierre-Emile Højbjerg | vs Manchester City | 85' | – | Premier League | 30 Dec 2018 |
| Pierre-Emile Højbjerg | vs Leicester City | 77' | – | Premier League | 25 Aug 2018 |
| Maya Yoshida | vs Everton | 85' | – | Premier League | 5 May 2018 |
| Jack Stephens | vs Arsenal | 90' | – | Premier League | 8 Apr 2018 |
| Virgil van Dijk | vs West Bromwich Albion | 89' | Mike Jones | Premier League | 31 Dec 2016 |
| Nathan Redmond | vs Tottenham Hotspur | 57' | J Moss | Premier League | 28 Dec 2016 |
| Sadio Mané | vs Stoke City | 90' | – | Premier League | 12 Mar 2016 |
| José Fonte | vs Sunderland | 79' | – | Premier League | 5 Mar 2016 |
| Victor Wanyama | vs West Ham United | 54' | – | Premier League | 6 Feb 2016 |
| Victor Wanyama | vs Norwich City | 73' | – | Premier League | 2 Jan 2016 |
| Victor Wanyama | vs AFC Bournemouth | 78' | – | Premier League | 1 Nov 2015 |
| Sadio Mané | vs Liverpool | 90' | – | Premier League | 25 Oct 2015 |
| James Ward-Prowse | vs Sunderland | 54' | – | Premier League | 2 May 2015 |
| Ryan Bertrand | vs Swansea City | 89' | – | Premier League | 1 Feb 2015 |
| Morgan Schneiderlin | vs Chelsea | 88' | – | Premier League | 28 Dec 2014 |
| Gastón Ramírez | vs West Bromwich Albion | 70' | – | Premier League | 27 Apr 2013 |
| Daniel Fox | vs West Bromwich Albion | 82' | – | Premier League | 27 Apr 2013 |