| Player | Opponent | Min | Referee | Competition | Date |
|---|---|---|---|---|---|
| Micky van de Ven | vs Crystal Palace | 38' | – | Premier League | 5 Mar 2026 |
| Cristian Romero | vs Manchester United | 29' | Michael Oliver | Premier League | 7 Feb 2026 |
| Xavi Simons | vs Liverpool | 33' | John Brooks | Premier League | 20 Dec 2025 |
| Cristian Romero | vs Liverpool | 90' | John Brooks | Premier League | 20 Dec 2025 |
| Brennan Johnson | vs F.C. København | 57' | Erik Lambrechts | UEFA Champions League | 4 Nov 2025 |
| Djed Spence | vs Nottingham Forest | 90' | Craig Pawson | Premier League | 26 Dec 2024 |
| Will Lankshear | vs Galatasaray | 60' | Lawrence Visser | UEFA Europa League | 7 Nov 2024 |
| Radu Dragusin | vs FK Qarabag | 7' | Willy Delajod | UEFA Europa League | 26 Sept 2024 |
| Yves Bissouma | vs Nottingham Forest | 70' | Jarred Gillett | Premier League | 15 Dec 2023 |
| Cristian Romero | vs Chelsea | 33' | Michael Oliver | Premier League | 6 Nov 2023 |
| Destiny Udogie | vs Chelsea | 55' | Michael Oliver | Premier League | 6 Nov 2023 |
| Yves Bissouma | vs Luton Town | 45' | John Brooks | Premier League | 7 Oct 2023 |
| Lucas Moura | vs Everton | 88' | David Coote | Premier League | 3 Apr 2023 |
| Cristian Romero | vs AC Milan | 77' | Clément Turpin | UEFA Champions League | 8 Mar 2023 |
| Cristian Romero | vs Manchester City | 87' | Andy Madley | Premier League | 5 Feb 2023 |
| Emerson Royal | vs Arsenal | 62' | Anthony Taylor | Premier League | 1 Oct 2022 |
| Japhet Tanganga | vs Crystal Palace | 58' | – | Premier League | 11 Sept 2021 |
| Erik Lamela | vs Arsenal | 76' | – | Premier League | 14 Mar 2021 |
| Matt Doherty | vs Leeds United | 90' | – | Premier League | 2 Jan 2021 |
| Son Heung-Min | vs Chelsea | 62' | Anthony Taylor | Premier League | 22 Dec 2019 |
| Son Heung-Min | vs Everton | 79' | – | Premier League | 3 Nov 2019 |
| Sèrge Aurier | vs Southampton | 31' | – | Premier League | 28 Sept 2019 |
| Son Heung-Min | vs AFC Bournemouth | 43' | – | Premier League | 4 May 2019 |
| Juan Foyth | vs AFC Bournemouth | 48' | – | Premier League | 4 May 2019 |
| Jan Vertonghen | vs Arsenal | 85' | – | Premier League | 2 Dec 2018 |
| Hugo Lloris | vs PSV Eindhoven | 79' | – | UEFA Champions League | 24 Oct 2018 |
| Davinson Sánchez | vs Watford | 52' | – | Premier League | 2 Dec 2017 |
| Sèrge Aurier | vs West Ham United | 70' | – | Premier League | 23 Sept 2017 |
| Jan Vertonghen | vs Borussia Dortmund | 90' | – | UEFA Champions League | 13 Sept 2017 |
| Dele Alli | vs KAA Gent | 39' | – | UEFA Europa League | 23 Feb 2017 |
| Vlad Chiriches | vs Stoke City | 51' | – | Premier League | 9 May 2015 |
| Kyle Naughton | vs Stoke City | 85' | – | Premier League | 9 Nov 2014 |
| Federico Fazio | vs Asteras Tripoli | 89' | – | UEFA Europa League | 6 Nov 2014 |
| Hugo Lloris | vs Asteras Tripoli | 87' | – | UEFA Europa League | 23 Oct 2014 |
| Federico Fazio | vs Manchester City | 67' | – | Premier League | 18 Oct 2014 |
| Kyle Naughton | vs West Ham United | 29' | – | Premier League | 16 Aug 2014 |
| Younes Kaboul | vs West Ham United | 25' | P Dowd | Premier League | 3 May 2014 |
| Younes Kaboul | vs Chelsea | 59' | Michael Oliver | Premier League | 8 Mar 2014 |
| Danny Rose | vs Manchester City | 50' | A Marriner | Premier League | 29 Jan 2014 |
| Paulinho | vs Liverpool | 63' | J Moss | Premier League | 15 Dec 2013 |
| Jan Vertonghen | vs FC Basel | 90' | Olegario Benquerenca | UEFA Europa League | 11 Apr 2013 |
| Emmanuel Adebayor | vs Arsenal | 18' | Howard Webb | Premier League | 17 Nov 2012 |
| Tom Huddlestone | vs Norwich City | 89' | – | Premier League | 1 Sept 2012 |
| Danny Rose | vs Aston Villa | 50' | – | Premier League | 6 May 2012 |
| Scott Parker | vs Arsenal | 87' | M Dean | Premier League | 26 Feb 2012 |
| Younes Kaboul | vs Stoke City | 82' | C Foy | Premier League | 11 Dec 2011 |
| Peter Crouch | vs Real Madrid | 15' | Felix Brych | UEFA Champions League | 5 Apr 2011 |
| Younes Kaboul | vs Newcastle United | 66' | A Taylor | Premier League | 28 Dec 2010 |
| Jermain Defoe | vs Aston Villa | 27' | M Atkinson | Premier League | 26 Dec 2010 |
| Heurelho Gomes | vs Internazionale | 8' | Damir Skomina | UEFA Champions League | 20 Oct 2010 |
| Rafael van der Vaart | vs FC Twente | 61' | Terje Hauge | UEFA Champions League | 29 Sept 2010 |